We have already about 75 disciples in the Cherokee Nation, which we humbly hope and pray may be the first fruits of a glorious harvest. Some of these are the result of our humble efforts in the old nation more than twenty years ago. Some are the fruits of the able efforts of Bro. Graham, and the pious labors of Bro. Robertson; and some 50 were converted by the zealous efforts of brethren Goodnight and Phillips. We had the pleasure last fall of immersing three descendants of the red man, while on a visit to Grand Prairie, where we have a good prospect of establishing a High School. Having volunteered our humble efforts in this missionary field, free of charges to church or state, and having a large family to care for, we have not been able to devote as much time to preaching the word as we desired, and the cause demands.
Trott's report indicates that he was enjoying at least some success in his mission. It also tells us that he worked among a network of fellow preachers. At least some of those men resided in northwest Arkansas and made trips across the border into Indian Territory in order to preach to Cherokees.
But in 1862, troops entered the Cherokee Nation confiscating goods as they went. They helped themselves to provisions that belonged to Trott, and one of his sons, Timothy, was killed. At this, the family fled to Arkansas, and then to Missouri. Eventually, they found refuge in Kansas, but not before one of Trott's daughters, Elizabeth, died from exposure on Christmas Day 1862.
One might guess that after the war, Trott would have stayed in Kansas, where the Disciples had made him the state evangelist, or gone back to Tennessee, where he had many friends and family. But in June of 1866, he returned to the Indian Territory to once again work among the Cherokees. Nevertheless, by that time deprivation and depression had taken their toll.
In 1868, James Trott set out for Tennessee, and died on December 19, 1868, not long after he arrived. He lies buried in Carmack Cemetery in Sumner County.
 J. Edward Moseley, Disciples of Christ in Georgia (St. Louis: Bethany Press, 1954), 130.
 Report of the Proceedings of the Anniversary Meeting of the American Christian Missionary Society Held in Cincinnati, October 23, 24, 25, 1860 (Cincinnati: H. S. Bosworth, 1860), p. 16.
 Moseley, Disciples of Christ in Georgia, 130-31; Tolbert Fanning, "James J. Trott: Messenger of the Church of Christ at Franklin College, Tenn., to the Cherokee Nation," Gospel Advocate (March 25, 1869).